Skin-care products aren’t known for instant gratification, but using the best wrinkle cream proves the power of patience. While no cream can reverse signs of aging altogether, early and consistent use of these superhero formulas can soften fine lines, tighten and plump skin, and even tone over time. And while we think aging skin is something to celebrate, we get it if you’re not quite ready to embrace the changes.

These potent moisturizers are formulated with active ingredients—like peptides, hyaluronic acid, retinol, and ceramides (to name a few)—designed to temporarily improve the appearance of fine lines and wrinkles while making up for lost moisture. We tapped dermatologists to learn which wrinkle serums and creams actually work—here are the best 10.

Our Top Wrinkle Creams

• Best Wrinkle Cream Overall: Alastin Restorative Skin Complex with TriHex+, $258
• Best for Dry Skin: Lancôme Rénergie H.P.N. 300-Peptide Anti-Aging Cream, $150
• Best for Deep Wrinkles: SkinCeuticals A.G.E. Interrupter Advanced, $185
• Best for Barrier Support: Ourself Daily Renewal Cream Rich, $85
• Best for Sensitive Skin: RoC Retinol Correxion Max Daily Hydration Fragrance Free Cream, $35
• Best for Hyperpigmentation: Shiseido Vital Perfection Uplifting and Firming Advanced Cream, $145
• Best Firming: Neocutis BioSerum Firm, $290
• Best for Lax Skin: Isdin Isdinceutics Age Contour Night Face Moisturizer, $145
• Best for Expression Lines: Revision Skincare Revox 7, $150
• Best Drugstore: Olay Regenerist Micro-Sculpting Cream, $27

Best Wrinkle Cream Overall: Alastin Restorative Skin Complex with TriHex+

Why we love it: Skin changes with time—that’s natural—but Alastin Restorative Skin Complex with TriHex+ helps it stay resilient, supported, and visibly vibrant at every stage. TriHex+ is the brand’s patented blend of peptides designed to clear out old, damaged collagen and elastin while signaling the skin to produce fresh, healthy fibers in their place (in other words, think of it as a cleanup crew and a construction team in one). The recently updated formula steps things up with octapeptide-45 to further support collagen, elastin, and hyaluronic acid, plus magnolol to calm inflammation and l-ornithine to help visibly firm and re-plump thinning areas. Whether you’re in between treatments or just want to keep skin looking supported and firm, this serum-like consistency sinks in quickly, making it easy to fit into any routine (and worthy of its luxury price point).

Best for Dry Skin: Lancôme Rénergie H.P.N. 300-Peptide Anti-Aging Cream

Why it's worth it: H.P.N. is an acronym for the three star ingredients doing the heavy lifting in this formula: hyaluronic acid, peptides (over 300 of them!), and niacinamide. Together, “Lancôme’s Rénergie H.P.N. 300-Peptide Anti-Aging Cream is a multi-tasking formula that helps firm, smooth, and brighten the skin,” says Whitney Hovenic, MD, a board-certified dermatologist based in Reno, Nevada. The peptides help support collagen and elasticity, niacinamide improves tone and radiance, and hyaluronic acid pulls in deep moisture—making tight, dehydrated skin feel cushioned again. As Dr. Hovenic explains, “The texture feels rich but absorbs quickly, leaving skin hydrated, supple, and visibly more radiant with continued use.”

Best for Deep Wrinkles: SkinCeuticals A.G.E. Interrupter Advanced

Why we love it: A.G.E. doesn’t actually stand for “age” (even though it’s fitting); it’s short for advanced glycation end-products, which are basically sticky sugar-protein bonds that gunk up your collagen over time and lead to deeper wrinkles, sagging, and that crepey look on the face, neck, and chest. SkinCeuticals’ A.G.E. Interrupter Advanced was made to slow that process down and help undo some of the visible effects. The featured ingredient is proprietary 18% Proxylane, a molecule that helps rebuild the skin’s “support beams,” making it look firmer and more cushioned. The formula also packs 4.25% blueberry and pomegranate flavonoids to help defend against sugar and environmental damage, plus 0.1% licorice-derived glycyrrhetinic acid to calm and brighten. It’s richer than a standard moisturizer, but that’s on purpose—it’s meant for skin dealing with deeper lines, loss of density, and dryness.

Best for Barrier Support: Ourself Daily Renewal Cream Rich

Why we love it: The “Rich” version of Ourself’s Daily Renewal Cream is made for the moments your skin needs extra support: after a peel, during freezing cold-weather months, or when your face just feels dry and overworked. “It’s a favorite for those with dry skin, which is especially important as we go into the winter months,” says Dr. Hovenic. The formula relies on the brand’s Intides (a.k.a. “intelligent peptides”), niacinamide, hyaluronic acid, and ginger root extract to hydrate, even tone, and calm irritation. Then shea butter and carob fruit extract step in to “provide deep nourishment and strengthen the skin’s barrier function,” says Dr. Hovenic. Thanks to its slow-release delivery tech, the comfort actually lasts—“skin feels nourished and protected all day long,” she adds.

Best for Sensitive Skin: RoC Retinol Correxion Max Daily Hydration Fragrance Free Cream

Why we love it: You might be surprised that our pick for sensitive skin includes retinol, but hear us out. RoC Retinol Correxion Max Daily Hydration Fragrance Free Cream pairs retinol (the gold-standard wrinkle fighter) with hyaluronic acid to cushion skin against the dryness and irritation retinol is known for. “This is a wrinkle-fighting cream for sensitive and dry skin, using both hyaluronic acid for short-term plumping and retinol for long-term results,” says Peter Bittar, MD, a board-certified dermatologist based in Miami. The formula also includes soothing hydrators such as glycerin, dimethicone, and glyceryl behenate, plus antioxidants (vitamin E and C derivatives) to help calm and protect the skin. “Since it’s fragrance-free, it minimizes irritation,” and is a gentle entry point for anyone who wants retinol results without the rough side effects, says Dr. Bittar.

Best for Hyperpigmentation: Shiseido Vital Perfection Uplifting and Firming Advanced Cream

Why we love it: If your main concerns are uneven tone and dark spots, along with loss of firmness, Shiseido’s Vital Perfection Uplifting and Firming Advanced Cream targets all three at once. The formula’s hero, SafflowerRED (grown exclusively in Japan), helps lift, firm, and visibly even the complexion, while ziziphus jujuba fruit extract zeroes in on hyperpigmentation and elasticity. Ginseng root extract supports natural collagen production for brighter, stronger skin, and caffeine adds a quick-hit brightening effect while helping soften the look of lines. Plus, a mix of gentle botanicals—like rosemary, green tea, and angelica root—helps calm, hydrate, and maintain the moisture barrier, which is key if you want that firm-yet-glowy finish instead of tight, dry skin.

Best Firming: Neocutis BioSerum Firm

Why we love it: Nashville-based board-certified dermatologist Natalie M. Curcio, MD, is a fan of the Neocutis BioSerum Firm, which works as both a daytime and nighttime moisturizer. The formula combines growth factors and peptides for softer-looking fine lines and wrinkles, she says. P.S.: The growth factors are derived from cultured cells—no actual human tissue is involved. The brand says you’ll start seeing a difference in six days to keep antsiness at a minimum. If you prefer a richer formula or have really dry skin, consider Neocutis's BioCream Firme Riche. "The formulation has been shown to improve collagen and elastin production in as little as 14 days," says San Diego-based board-certified dermatologist Melanie Palm, MD.

Best for Lax Skin: Isdin Isdinceutics Age Contour Night Face Moisturizer

Why we love it: Packed with wrinkle smoothers like carnosine (a dipeptide naturally found in the body that declines with age) and niacinamide, the Isdin Isdinceutics Age Contour Night Face Moisturizer has won over Ava Shamban, MD, a board-certified dermatologist based in Los Angeles. The formula also has hyaluronic acid, which binds water to the skin cells, maintains the structural integrity of the skin's tissues, and stimulates collagen production, boosting thickness and firmness. When considering the "plumping" effect of hyaluronic acid in this nighttime moisturizer, Dr. Shamban says to think about the volume difference between a dry sponge and a wet sponge. "When wet, the sponge expands to occupy more space, giving a plumping effect," she says. The brand is known for adding melatonin to its products, which serves as an antioxidant to offset the effects of free radicals throughout the day.

Best for Expression Lines: Revision Skincare Revox 7

Why we love it: Want your skin care to work smarter, not harder? Try Revision Skincare’s Revox 7, which Rachel Nazarian, MD, a board-certified dermatologist at Schweiger Dermatology in New York City, calls "a fantastic product to help with wrinkles because it goes straight to the source." The cocktail of seven peptides targets the wrinkle-causing muscles to smooth out seven different expression lines.. Plus, she says, "It can be applied with your own moisturizer or under makeup twice a day."